α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.

a7-Cholinergic Receptor Mediates Vagal Induction of Splenic Norepinephrine

The ethereal Peter Parker, M.D., D.D.

nociceptive inputs. Prog Brain Res 1996; 113:525–39 33. Vida G, Peña G, Deitch EA, Ulloa L: 7-cholinergic receptor mediates vagal induction of splenic norepinephrine. J Immunol 2011; 186:4340 – 6 34. Leaders FE, Dayrit C: The cholinergic component in the sympathetic innervation to the spleen. J Pharmacol Exp Ther 1965; 147:145–52 35. Brandon, KW, Rand MJ: Acetylcholine and the sympathetic inner...

Expression and Function of the Cholinergic System in Immune Cells

T and B cells express most cholinergic system components-e.g., acetylcholine (ACh), choline acetyltransferase (ChAT), acetylcholinesterase, and both muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively). Using ChATBAC-eGFP transgenic mice, ChAT expression has been confirmed in T and B cells, dendritic cells, and macrophages. Moreover, T cell activation via T-cell receptor/CD3...

Usefulness of α7 nicotinic receptor messenger RNA levels in peripheral blood mononuclear cells as a marker for cholinergic antiinflammatory pathway activity in septic patients: results of a pilot study.

BACKGROUND Stimulation of the vagus nerve in the so-called cholinergic antiinflammatory pathway (CAP) attenuates systemic inflammation, improving survival in animal sepsis models via α7 nicotinic acetylcholine receptors on immunocompetent cells. Because the relevance of this regulatory pathway is unknown in human sepsis, this pilot study assessed whether the α7 gene expression level in septic p...

Direct positive inotropic effect of acetylcholine on myocardium. Evidence for multiple cholinergic receptors in the heart.

The effects of acetylcholine and nicotine on isometric tension, in the presence and absence of atropine, hexamethonium, and endogenous norepinephrine stores, were examined in isolated cat atria and papillary muscles. Acetylcholine exerted a negative inotropic effect, competitively inhibited by atropine, in atrial and papillary muscle; in higher concentrations in papillary muscles, it produced a...